WIKI4

SKU: orb1304577

Description

WIKI4 is a small molecule that potently inhibits tankyrase 2 (TNKS2) and suppresses canonical Wnt/β-catenin signaling. It is a valuable research tool for studying Wnt-driven pathologies in both cellular and animal models, including cancer and fibrosis.

Research Area

Epigenetics & Chromatin, Molecular Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 838818-26-1
• MW: 521.59
• Purity: 99.60% (May vary between batches)
• Formula: C₂₉H₂₃N₅O₃S
• SMILES: COc1ccc(cc1)-n1c(SCCCN2C(=O)c3cccc4cccc(C2=O)c34)nnc1-c1ccncc1
• Target: PARP|||Wnt/beta-catenin
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:7.14 mg/mL (13.69 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  TNKS2:15 nM
• In Vitro:
  WIKI4 inhibitsWnt/ -catenin signaling in all tested cell lines, including A375, DLD1 colorectal cancer, NALM6 B, U2OS osteosarcoma and hESCs. WIKI4 increases the steady-state abundance of theWnt/ -catenin inhibitory protein, AXIN1 by inhibiting tankyrase activity, and thus preventing the ubiquitylation and degradation of AXIN proteins.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Beta catenin, beta-catenin, betacatenin, bcatenin, Inhibitor, inhibit, PARP, β-catenin, βcatenin, Wnt, Wnt/b-catenin, Wnt/betacatenin, Wnt/β-catenin, WIKI 4, WIKI4, WIKI-4, poly ADP ribose polymerase, TNKS2

Compound Identifiers

PubChem CID

2984337