WIKI4

SKU: orb1223901

Description

A novel small molecule inhibitor of the Wnt/β-catenin pathway by inhibiting the enzymatic activity of TNKS2; prevents auto-ADP-ribosylation of TNKS2 with IC50 of 15 nM; inhibits expression of β-catenin target genes and cellular responses to Wnt/β-catenin signaling in cancer cell lines as well as in human embryonic stem cells.

Key Properties

• CAS Number: 838818-26-1
• MW: 521.5896
• Purity: >98% (HPLC)
• Formula: C₂₉H₂₃N₅O₃S
• SMILES: O=C(NC1=CC=CC=C1C(NC2=CC=C(CCN3CC4=C(C=C(OC)C(OC)=C4)CC3)C=C2)=O)C5=CC=C(OC)C(OC)=C5
• Target: Beta-catenin
• Solubility: DMSO: 6.8 mg/mL

Bioactivity

• In Vitro:
  Cell Viability Assay Cell line: DLD1 cells. Concentration: 100 nM, 1 μM. Incubation time: 6 days. Result: Inhibited growth of DLD1 cells. Western blot analysis. Cell line: DLD1 cells. Concentration: 1 μM. Incubation time: 2 hours, 4 hours, 6 hours, or 24 hours. Result: Significantly increased the steady-state abundance of AXIN1 and AXIN2.
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

WIKI-4

Quick Database Links

Gene Symbol

Beta-catenin