WEE1-IN-3

SKU: orb1298528

Description

WEE1-IN-3 (JUN76288) is a highly potent, sub-10 nM inhibitor of Wee1 kinase. This small molecule is a valuable research tool for investigating cell cycle regulation and has demonstrated utility in both in vitro and in vivo studies exploring novel cancer therapeutics.

Research Area

Cancer Biology, Cell Biology

Key Properties

• CAS Number: 2272976-28-8
• MW: 497.59
• Purity: 98.61% (May vary between batches)
• Formula: C₂₈H₃₁N₇O₂
• SMILES: CN1Cc2cc(Nc3ncc4c(n3)n(-c3cccc(n3)C(C)(C)O)n(CC=C)c4=O)ccc2C2(CC2)C1
• Target: Wee1
• Solubility: DMSO:250 mg/mL (502.42 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (10.05 mM)

Bioactivity

• Target IC50:
  Wee1:<10 nM
• In Vitro:
  WEE1-IN-3 inhibits cancer cell growth with IC50 values of 100-1000 nM and <100 nM for SW480 cells and H23 cells, respectively. WEE1 is overexpressed in various cancer types, WEE1 kinase plays a role in the G2-M cell-cycle checkpoint arrest for ΝΑ repair before mitotic entry. Normal cells repair damaged DNA during GI arrest. Cancer cells often have a deficient G i-S checkpoint and depend on a functional G2-M checkpoint for DNA repair.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, JUN 76288, JUN76288, JUN-76288, inhibit, cell, cycle, Anticancer, WEE1IN3, WEE-1-IN-3, WEE1-IN-3, WEE1 IN 3, Wee1

Compound Identifiers

PubChem CID

137471996