JUN76288

SKU: orb1218383

Description

JUN76288 is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. It treatment of cancer and other proliferative diseases.

Key Properties

• CAS Number: 2272976-28-8
• MW: 497.6
• Purity: >98% (HPLC)
• Formula: C₂₈H₃₁N₇O₂
• SMILES: CC(C)(C1=NC(=CC=C1)N2C3=NC(=NC=C3C(=O)N2CC=C)NC4=CC5=C(C=C4)C6(CC6)CN(C5)C)O
• Target: Wee1
• Solubility: DMSO:250 mg/mL (502.42 mM; Need ultrasonic)

Bioactivity

• In Vitro:
  WEE1-IN-3 (example 1) inhibits cancer cell growth with IC50 values of 100-1000 nM and < 100 nM for SW480 cells and H23 cells, respectively. WEE1 kinase plays a role in the G2-M cell-cycle checkpoint arrest for DNA repair before mitotic entry. Normal cells repair damaged DNA during G1 arrest. Cancer cells often have a deficient G1-S checkpoint and depend on a functional G2-M checkpoint for DNA repair. WEE1 is overexpressed in various cancer types.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

WEE1-IN-3

Quick Database Links

Gene Symbol

Wee1