Wedelolactone

SKU: orb1304253

Description

Wedelolactone (IKK Inhibitor II) is a cell-permeable inhibitor of IκB kinase (IKK) that prevents IκBα phosphorylation and degradation, thereby suppressing NF-κB activation and downstream gene transcription. This compound is widely used in vitro to study inflammatory signaling, apoptosis, and has shown research utility in animal models of liver injury and sepsis.

Research Area

Cell Biology, Metabolism Research, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 524-12-9
• MW: 314.25
• Purity: 99.87%
• Formula: C₁₆H₁₀O₇
• SMILES: COc1cc(O)c2c3oc4cc(O)c(O)cc4c3c(=O)oc2c1
• Target: Caspase,Lipoxygenase,NF-κB,Apoptosis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5.7 mg/mL (18.14 mM);DMSO:252.5 mg/mL (803.5 mM);Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble

Bioactivity

• Target IC50:
  5-LOX:2.5 μM (IC50)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, cancer, Caspase, BMSC, Inhibitor, IKK Inhibitor II, Eclipta alba, inhibit, Lipoxygenase, LOX, migration, NF-κB, NFκB, NFkB, NF-kB, osteoclast, Wedelia chinensis, Wedelolactone, prostate

Compound Identifiers

PubChem CID

5281813