WDR5-0103

SKU: orb1304431

Description

WDR5-0103 is a potent and selective small molecule antagonist of the WD Repeat Domain 5 (WDR5) protein, exhibiting a binding affinity (Kd) of 450 nM. This inhibitor is a valuable chemical probe for investigating the role of WDR5 in chromatin remodeling, gene regulation, and cancer biology in both cellular and biochemical assays.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 890190-22-4
• MW: 383.44
• Purity: 99.96% (May vary between batches)
• Formula: C₂₁H₂₅N₃O₄
• SMILES: COC(=O)c1ccc(N2CCN(C)CC2)c(NC(=O)c2cccc(OC)c2)c1
• Target: JAK,Histone Methyltransferase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.22 mM);DMSO:60 mg/mL (156.48 mM)

Bioactivity

• Target IC50:
  WDR5:450 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

WDR5, WDR50103, WDR-5-0103, WDR5-0103, WD-Repeat Protein 5-0103, WDR5 0103, inhibit, Inhibitor, HistoneMethyltransferase, Histone Methyltransferase

Compound Identifiers

PubChem CID

6457069