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WDR5-0103

SKU: orb1304431

Description

WDR5-0103 is a potent and selective small molecule antagonist of the WD Repeat Domain 5 (WDR5) protein, exhibiting a binding affinity (Kd) of 450 nM. This inhibitor is a valuable chemical probe for investigating the role of WDR5 in chromatin remodeling, gene regulation, and cancer biology in both cellular and biochemical assays.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number890190-22-4
MW383.44
Purity99.96% (May vary between batches)
FormulaC21H25N3O4
SMILESCOC(=O)c1ccc(N2CCN(C)CC2)c(NC(=O)c2cccc(OC)c2)c1
TargetJAK|||Histone Methyltransferase
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.22 mM);DMSO:60 mg/mL (156.48 mM)

Bioactivity

Target IC50
WDR5:450 nM

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

WDR5, WDR50103, WDR-5-0103, WDR5-0103, WD-Repeat Protein 5-0103, WDR5 0103, inhibit, Inhibitor, HistoneMethyltransferase, Histone Methyltransferase

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

5 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 80.00
10 mg
$ 110.00
25 mg
$ 180.00
50 mg
$ 280.00
100 mg
$ 390.00
200 mg
$ 530.00
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