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VX-222

SKU: orb1227122

Description

A potent and selective, nonnucleoside inhibitor of HCV NS5B polymerase inhibitor with Kd of 17 nM; inhibits the 1b/Con1 HCV subgenomic replicon with EC50 of 17 nM, the M423I and A486S variants remaine susceptible to VX-222; exhibits non-competitive and selective inhibition in HCV NS5B of genotype 1a and 1b, with IC50 of 0.94 and 1.2 uM, respectively; displays fine pharmacokinetic pro le in rats and dogs.HCV Infection Phase 2 Discontinued.

Images & Validation

Key Properties

CAS Number1026785-59-0
MW445.6147
Purity>98% (HPLC)
FormulaC25H35NO4S
SMILESCC1CCC(CC1)C(=O)N(C2CCC(CC2)O)C3=C(SC(=C3)C#CC(C)(C)C)C(=O)O
TargetHCV
SolubilityDMSO: ≥ 32 mg/mL

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

VCH-222 | Lomibuvir

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Protocol Information

VX-222 (orb1227122)

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Available Sizes

Select a size below

100 mg
200 mg
500 mg
2 mg
$ 140.00
5 mg
$ 230.00
10 mg
$ 370.00
25 mg
$ 740.00
50 mg
$ 1,070.00