VU533

SKU: orb2900484

Description

APE-PLD (VU533) activator is a potent NAPE-PLD activator with an EC50 value of 0.30 μM. NAPE-PLD activator (VU533) can enhance NAPE-PLD activity and increase efferocytosis by macrophages. NAPE-PLD activator (VU533) can be used for cardiometabolic diseases research.

Key Properties

• CAS Number: 923417-09-8
• MW: 447.55
• Purity: >98% (HPLC)
• Formula: C₂₁H₂₂FN₃O₃S₂
• SMILES: CC1=CC=C(C)C2=C1SC(NC(=O)C1CCN(CC1)S(=O)(=O)C1=CC=C(F)C=C1)=N2
• Target: Phospholipase
• Solubility: In Vitro: DMSO : 125 mg/mL (279.30 mM; Ultrasonic (<60°C)

Bioactivity

• In Vitro:
  Cell Cytotoxicity Assay Cell line: RAW264.7, HepG2 Concentration: 0.1-30 μM Incubation time: 24 h. Result: Showed no cytotoxicity when tested at 30 μM in either RAW264.7 or HepG2 cells. Cell Autophagy Assay Cell line: BMDM. Concentration: 10 μM. Incubation time: 6 h. Result: Enhanced efferocytosis compared to vehicle treated BMDM at 10 μM.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Phospholipase