VU533

SKU: orb1819038

Description

VU533 is a potent small molecule activator of NAPE-PLD, exhibiting an EC50 of 0.30 µM. It enhances enzyme activity, promotes macrophage cytosolic lipid burial, and serves as a valuable research tool for studying cardiometabolic diseases in cellular and in vivo models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 923417-09-8
• MW: 447.55
• Purity: 99.87%
• Formula: C₂₁H₂₂FN₃O₃S₂
• SMILES: CC1=CC=C(C)C2=C1SC(NC(=O)C1CCN(CC1)S(=O)(=O)C1=CC=C(F)C=C1)=N2
• Target: Phospholipase
• Solubility: DMSO:16.67 mg/mL (37.25 mM)

Bioactivity

• Target IC50:
  NAPE-PLD:0.30 μM(EC50)
• In Vitro:
  VU533 (NAPE-PLD activator) (0.1-30 μM; 24 h) is non-cytotoxic to RAW264.7 and HepG2 cells. VU533 (0.1-30 μM; 24 h) increases NAPE-PLD activity in a concentration-dependent manner in RAW264.7 cells and HepG2 cells. VU533 (10 μM; 6 h) increases efferocytosis of bone marrow-derived macrophages (BMDM) isolated from wild-type mice.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PLD, Nape-Pld activator, VU533, VU-533, VU 533

Compound Identifiers

PubChem CID

16831624