VU0357017 hydrochloride

SKU: orb1303991

Description

VU0357017 hydrochloride is a highly selective, allosteric agonist of the M1 muscarinic receptor with an EC50 of 477 ± 172 nM. This research compound is utilized in vitro and in vivo to investigate M1 receptor function in contexts such as cognitive disorders and central nervous system research.

Research Area

Neuroscience

Key Properties

• CAS Number: 1135242-13-5
• MW: 369.89
• Purity: 99.97% (May vary between batches)
• Formula: C₁₈H₂₈ClN₃O₃
• SMILES: Cl.CCOC(=O)N1CCC(CC1)NCCNC(=O)c1ccccc1C
• Target: AChR
• Solubility: DMSO:33 mg/mL (89.22 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.41 mM)

Bioactivity

• Target IC50:
  M1:477 ± 172 nM (EC50)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Muscarinic acetylcholine receptor, muscarinic, inhibit, M1 mAChR, mAChR, ML071 hydrochloride, ML071 Hydrochloride, ML-071 Hydrochloride, ML 071 Hydrochloride, Inhibitor, CID25010775, CID-25010775, CID 25010775, acetylcholine,Alzheimer's, VU0357017, VU-0357017, VU0357017 Hydrochloride, VU0357017 hydrochloride, VU-0357017 Hydrochloride, VU-0357017 hydrochloride, VU 0357017, VU 0357017 hydrochloride, VU 0357017 Hydrochloride, schizophrenia

Compound Identifiers

PubChem CID

25010775

Paulina Cieślik 1, Anna Rafało-Ulińska 1, Joanna M Wierońska Prevention of MK-801-induced amnestic effect with combined activation of 5-HT1A and muscarinic receptors in mice Pharmacol Biochem Behav, (2024)

PubMed: 38462045