VU0155041

SKU: orb1304054

Description

VU0155041 is a potent positive allosteric modulator and agonist at mGlu4 receptors, with EC50 values of 798 nM and 693 nM for human and rat receptors, respectively. This compound is a valuable research tool for investigating the role of mGlu4 in neurological disorders, including Parkinson's disease, in both in vitro and in vivo experimental models.

Research Area

Neuroscience

Key Properties

• CAS Number: 1093757-42-6
• MW: 316.18
• Purity: >99.99% (May vary between batches)
• Formula: C₁₄H₁₅Cl₂NO₃
• SMILES: OC(=O)[C@H]1CCCC[C@H]1C(=O)Nc1cc(Cl)cc(Cl)c1
• Target: GluR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.33 mM);DMSO:31.6 mg/mL (99.94 mM)

Bioactivity

• Target IC50:
  mGlu4 (human):798nM(EC50)|mGlu4 (rat):693 nM(EC50)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, glutamate, inhibit, partial, mGluR, mGluR4, Metabotropic glutamate receptors, UV0155041, UV-0155041, UV 0155041, VU 0155041, VU0155041, VU-0155041

Compound Identifiers

PubChem CID

888026