(1R,2S)-VU0155041

SKU: orb1708152

Description

VU0155041 (cis) is the cis-regioisomer of VU0155041 and acts as a partial agonist at the mGluR4 receptor. This compound is utilized in neuroscience research to investigate the role of mGluR4 in vitro and in vivo, particularly in studies related to Parkinson's disease and neuroprotection.

Research Area

Neuroscience

Key Properties

• CAS Number: 1263273-14-8
• MW: 316.18
• Purity: 99.73% (May vary between batches)
• Formula: C₁₄H₁₅Cl₂NO₃
• SMILES: OC(=O)[C@@H]1CCCC[C@@H]1C(=O)Nc1cc(Cl)cc(Cl)c1
• Target: GluR
• Solubility: 10% DMSO+90% Corn Oil:2.5 mg/mL (7.91 mM);DMSO:54 mg/mL (170.79 mM)

Bioactivity

• Target IC50:
  mGluR4 (rat):(EC50)2.35 μM
• In Vitro:
  (1R,2S)-VU0155041 is similar in potency with VU0155041 At both human and rat receptors (798 nM at human mGluR4 and 693 nM at rat mGluR4). (1R,2S)-VU0155041 (30 μM) induces concentration-dependent shifts in the baseline when examined in fold shift experiments using the thallium flux assay.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(1R,2S) VU0155041, (1R,2S)VU0155041, (1R,2S)-VU-0155041, mGluR4, rat mGluR4, VU 0155041, VU0155041, VU-0155041

Compound Identifiers

PubChem CID

888023