VU0071063

SKU: orb1218151

Description

VU0071063 is a Kir6.2/SUR1 activator.

Key Properties

• CAS Number: 333415-38-6
• MW: 326.4
• Purity: >98% (HPLC)
• Formula: C₁₈H₂₂N₄O₂
• SMILES: O=C(N1C)N(C)C2=C(N(CC3=CC=C(C(C)(C)C)C=C3)C=N2)C1=O
• Target: Potassium Channel
• Solubility: DMSO:10 mM

Bioactivity

• In Vivo:
  VU0071063 (50 mg/kg; i.p.; 4 hours) leads to a significant increase in blood glucose at 60 minutes. Animal model: Male C57BL/6 mice (10-12 weeks age). Dosage: 50 mg/kg (Pharmacokinetic analysis). Administration: i.p. Result: Led to a significant increase in blood glucose at 60 minutes.
• In Vitro:
  VU0071063 (1 nM~1 mM; HEK-293 cells) dose dependently opens Kir6.2/SUR1. VU0071063 (0~20 μM; isolated cells) inhibits β-Cell excitability in mouse Islets. VU0071063 (10 μM; 1 hour; isolated cells) inhibits glucose-stimulated insulin secretion. VU0071063 dose dependently and reversibly hyperpolarizes the β-cell membrane potential, which, in turn, inhibits glucose-stimulated Ca2+ entry and insulin secretion. The actions of VU0071063 on the β-cell membrane potential are reversed by tolbutamide, and glucose stimulated insulin secretion is unaffected by the inactive analog 34MT, indicating that the effects are mediated through Kir6.2/SUR1.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

VU-0071063 | VU 0071063

Quick Database Links

Gene Symbol

Potassium Channel