VT104

SKU: orb2900613

Description

VT104 is a potent and orally active YAP/TAZ inhibitor. VT104 prevents palmitoylation of endogenous TEAD1 and TEAD3 proteins. VT104 can be used in research of cancer.

Key Properties

• CAS Number: 2417718-25-1
• MW: 420.43
• Purity: >98% (HPLC)
• Formula: C₂₅H₁₉F₃N₂O
• SMILES: C[C@H](NC(=O)c1ccc2c(cccc2c1)-c1ccc(cc1)C(F)(F)F)c1ccccn1
• Solubility: In Vitro: DMSO : 100 mg/mL (237.85 mM; Ultrasonic )

Bioactivity

• In Vivo:
  Animal model: NCI-H226-tumor bearing mice. Dosage: 0.3, 1, and 3 mg/kg. Administration: Oral administration. Result: Blocked NCI-H226 tumor growth in mice in dose-dependent manner.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only