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VT104

SKU: orb2900613

Description

VT104 is a potent and orally active YAP/TAZ inhibitor. VT104 prevents palmitoylation of endogenous TEAD1 and TEAD3 proteins. VT104 can be used in research of cancer.

Images & Validation

Key Properties

CAS Number2417718-25-1
MW420.43
Purity>98% (HPLC)
FormulaC25H19F3N2O
SMILESC[C@H](NC(=O)c1ccc2c(cccc2c1)-c1ccc(cc1)C(F)(F)F)c1ccccn1
SolubilityIn Vitro: DMSO : 100 mg/mL (237.85 mM; Ultrasonic )

Bioactivity

In Vivo
Animal model: NCI-H226-tumor bearing mice. Dosage: 0.3, 1, and 3 mg/kg. Administration: Oral administration. Result: Blocked NCI-H226 tumor growth in mice in dose-dependent manner.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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  • VT104 [orb1741387]

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    2417718-25-1

    420.43

    C25H19F3N2O

    1 mg, 5 mg, 10 mg, 25 mg, 1 ml x 10 mM (in DMSO), 50 mg, 100 mg
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Protocol Information

VT104 (orb2900613)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
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% Tween 80 +
%

Available Sizes

Select a size below

500 mg
2 mg
$ 170.00
5 mg
$ 330.00
10 mg
$ 510.00
25 mg
$ 790.00
50 mg
$ 1,090.00
100 mg
$ 1,420.00