VT104

SKU: orb1741387

Description

VT104

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2417718-25-1
• MW: 420.43
• Purity: 99.52%
• Formula: C₂₅H₁₉F₃N₂O
• SMILES: C[C@H](NC(=O)c1ccc2c(cccc2c1)-c1ccc(cc1)C(F)(F)F)c1ccccn1
• Target: YAP
• Solubility: DMSO:30 mg/mL (71.36 mM)

Bioactivity

• In Vivo:
  METHODS: Mice after MET+CTNNB1-S45Y HTVI were treated with VT104 (10 mg/kg/day) for 6 weeks. RESULTS VT104 strongly inhibited HCC development in vivo driven by MET+CTNNB1-S45Y; VT104 significantly reduced Ki67+ proliferation and γH2AX-positive hepatocytes.
• In Vitro:
  METHODS: Huh7 cells were treated with the pan-TEAD inhibitor VT104 (0.1, 0.5, 1, 2.5, 5 μM) for 72 h and then subjected to WST assay to assess cell number or 24 h for qPCR of ANKRD1, ANLN, and KIF23. RESULTS VT104 reduced Huh7 cell proliferation and inhibited the TAZ-TEAD pathway, with reduced expression of TAZ-TEAD targets ANLN, KIF23, ANKRD1, CTGF, and CD274 in Huh7 cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

YAP–TEAD, YAP

Compound Identifiers

PubChem CID

146909371