Vps34-IN-1

SKU: orb1300142

Description

Vps34-IN-1 is a potent and selective inhibitor of Vps34, demonstrating an in vitro IC50 of 25 nM with minimal activity against class I and II PI3K isoforms. It is a valuable chemical tool for studying autophagy, endosomal trafficking, and related pathways in both cellular and in vivo research contexts.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1383716-33-3
• MW: 425.91
• Purity: 97.04%
• Formula: C₂₁H₂₄ClN₇O
• SMILES: CC(C)(O)CNc1ncc(c(CC2CC2)n1)-c1ccnc(Nc2ccnc(Cl)c2)n1
• Target: PI3K,Autophagy
• Solubility: Ethanol:79 mg/mL (185.49 mM);DMSO:79 mg/mL (185.49 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.7 mM)

Bioactivity

• Target IC50:
  VPS34:25 nM
• In Vitro:
  Administration of VPS34-IN1 to cells induces a rapid dose-dependent dispersal of a specific PtdIns(3)P-binding probe from endosome membranes, within 1min, without affecting the ability of class I PI3K to regulate Akt. It can also induce a rapid ~50-60% loss of SGK3 phosphorylation within 1min. VPS34-IN1 has no inhibition to the SGK2 isoform that does not possess a PtdIns(3)P-binding PX domain.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, inhibit, Inhibitor, PI3K, Phosphoinositide 3-kinase, Vps34, Vps34IN1, Vps-34-IN-1, VPS34-IN1, Vps34-IN-1, Vps34 IN 1

Compound Identifiers

PubChem CID

57404276