Vps34-IN-1

SKU: orb1226399

Description

Vps34-IN-1 is a potent, selective inhibitor of class III PI3K Vps34 with IC50 of 25 nM, does not inhibit class I and II PI3Ks, as well as a broad panel of protein kinases or lipid kinases; rapidly reduces endosomal PtdIns(3)P levels, induces a rapid ~50-60% loss of SGK3 phosphorylation in cells, does not inhibit activity of the SGK2 isoform; Vps34-IN1 is a useful probe to delineate physiological roles of the Vps34.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1383716-33-3
• MW: 425.9146
• Purity: >98% (HPLC)
• Formula: C₂₁H₂₄ClN₇O
• SMILES: OC(C)(C)CNC(N=C1CC2CC2)=NC=C1C3=CC=NC(NC4=CC=NC(Cl)=C4)=N3
• Target: PI3K
• Solubility: DMSO: ≥ 31 mg/mL

Bioactivity

• In Vitro:
  Western blot analysis. Cell line: MHH97H and Huh7 cells. Concentration: 1, 2, 4 μM. Incubation time: 24 h. Result: Induced a dose-dependent inhibition of SGK3 phosphorylation in MHH97H and Huh7 cells.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Vps34-IN1

Quick Database Links

Gene Symbol

PI3K