Vonoprazan

SKU: orb1745262

Description

Vonoprazan (TAK-438) is a potassium-competitive acid blocker (P-CAB) used in research for acid-related disorders. It is employed in in vitro binding assays and in vivo models to study its potent and long-lasting inhibition of gastric acid secretion for conditions like ulcers and reflux esophagitis.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 881681-00-1
• MW: 345.39
• Purity: 99.87% (May vary between batches)
• Formula: C₁₇H₁₆FN₃O₂S
• SMILES: CNCc1cc(-c2ccccc2F)n(c1)S(=O)(=O)c1cccnc1
• Target: Proton pump,Antibacterial
• Solubility: DMSO:100 mg/mL (289.53 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (11.58 mM)

Bioactivity

• Target IC50:
  H+, K+ ATPase (porcine gastric, at pH 6.5):19 nM (IC50)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

reflux, Protonpump, Proton pump, Proton Pump, proton, potassium-competitive acid, peptic, potassium, TAK 438, TAK438, TAK-438, TAK-438 (free base), pump, ulcer, Vonoprazan, blocker, Bacterial, antisecretory, acid, disease, competitive, GERD, gastric, gastroesophageal, inhibitor, secretion, P-CAB, inhibit

Compound Identifiers

PubChem CID

15981397