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Vonoprazan hydrochloride
Catalog Number: orb1688393
| Catalog Number | orb1688393 |
|---|---|
| Category | Small Molecules |
| Description | Vonoprazan hydrochloride |
| CAS Number | 1957202-44-6 |
| Purity | 98% |
| MW | 381.85 |
| SMILES | Cl.CNCc1cc(-c2ccccc2F)n(c1)S(=O)(=O)c1cccnc1 |
| Formula | C17H17ClFN3O2S |
| Biological Activity | Vonoprazan hydrochloride, a proton pump inhibitor (PPI), effectively acts as a potassium-competitive acid blocker (P-CAB) with potent antisecretory activity. It notably inhibits H+,K+-ATPase activity in porcine gastric microsomes, demonstrating an IC50 of 19 nM at pH 6.5. Primarily developed for researching acid-related diseases like gastroesophageal reflux disease and peptic ulcer disease, vonoprazan hydrochloride also serves in the eradication of Helicobacter pylori [1] [2] [3]. |
| Storage | -20°C |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
