Vonoprazan Fumarate

SKU: orb1306422

Description

Vonoprazan Fumarate

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 881681-01-2
• MW: 461.46
• Purity: 98.94%
• Formula: C₂₁H₂₀FN₃O₆S
• SMILES: OC(=O)\C=C\C(O)=O.CNCc1cc(-c2ccccc2F)n(c1)S(=O)(=O)c1cccnc1
• Target: Proton pump
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.17 mM);DMSO:4.62 mg/mL (10.01 mM)

Bioactivity

• Target IC50:
  H+, K+-ATPase:19 nM
• In Vivo:
  Vonoprazan Fumurate, at a dose of 4 mg/kg (as the free base) orally, completely inhibited basal and 2-deoxy-d-glucose-stimulated gastric acid secretion in rats, and its effect on both was stronger than that of lansoprazole. Vonoprazan Fumurate increased the pH of gastric perfusate to a higher value than did lansoprazole or SCH28080, and the effect of Vonoprazan Fumurate was sustained longer than that of lansoprazole or SCH28080.
• In Vitro:
  The inhibitory activity of Vonoprazan Fumurate was unaffected by ambient pH. The inhibition by Vonoprazan Fumurate was reversible and achieved in a K(+)-competitive manner, quite different from that by lansoprazole. Vonoprazan Fumurate exhibits porcine gastric H+ ,K+-ATPase activity in a concentration-dependent manner.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, P-CAB, GERD, inhibitor, gastroesophageal, gastric, competitive, disease, blocker, antisecretory, 1260141-27-2, acid, secretion, peptic, potassium, reflux, pump, Proton pump, Proton Pump, proton, Protonpump, TAK438, TAK-438, TAK 438, T2404, ulcer, Vonoprazan, Vonoprazan Fumarate, Vonoprazan Fumurate

Compound Identifiers

PubChem CID

45375887