Volagidemab Antibody

SKU: orb1980568

Description

Volagidemab (AMG-477) is a monoclonal antibody and glucagon receptor (GCGR) antagonist used in metabolic research. It is applied in preclinical studies for type 1 diabetes and hypoglycemia, investigating GCGR blockade in both in vitro assays and in vivo models.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	1233956-13-2
MW	147 kDa
Purity	95.00%
Target	Glucagon Receptor

Bioactivity

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In Vivo	Subcutaneous injection of 5 mg/kg Volagidemab suppresses the phenotype of type 1 diabetes in a mouse model of tetracycline-induced diabetes.

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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AMG477, AMG-477, Glucagon Receptor, GlucagonReceptor, GCGR, REMD477, REMD-477

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Gene Symbol

Glucagon Receptor

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