Vicenin -2

SKU: orb1218341

Description

Vicenin 2 is an angiotensin-converting enzyme (ACE) inhibitor (IC50=43.83 μM) from the aerial parts of Desmodium styracifolium. Vicenin 2 is an inhibitor of α-glucosidase, PTP1B, and RLAR. Vicenin -2 has hepatoprotective, anti-cancer, antioxidant and anti-inflammatory activities, and DTL co-administration is more effective than either of the single agents in androgen-independent prostate cancer. Vicenin -2 might be a useful lead for the development of multiple target-oriented therapeutic modalities for the treatment of diabetes and diabetes-associated complications. Vicenin -2 could act as a UV light barrier to protect the plants.

Key Properties

• CAS Number: 23666-13-9
• MW: 594.5
• Purity: >98% (HPLC)
• Formula: C₂₇H₃₀O₁₅
• SMILES: C1=CC(=CC=C1C2=CC(=O)C3=C(C(=C(C(=C3O2)[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O)[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O)O)O
• Target: RAAS
• Solubility: DMSO:10 mM

Bioactivity

• In Vivo:
  Animal model: Male C57BL/6J mice (25 g) treated with Dextran sulfate sodium (DSS). Dosage: 50 mg/kg. Administration: Orally administration; for 7 days. Result: Effectively suppressed DSS-induced colitis by attenuating expressions of key inflammatory mediators.
• In Vitro:
  Cell Viability Assay Cell line: NCI-H23 cells. Concentration: 10 μM, 20 μM, 30 μM, 40 μM, 50 μM, 60 μM, 70 μM, 80 μM, 90 μM, 100 μM. Incubation time: 24 hours. Result: Showed cytotoxic effect on NCI H23 cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

RAAS