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VHL Ligand 38

SKU: orb3174158

Description

VHL Ligand 38 (Compound 1) is a competitive inhibitor of the E3 ubiquitin ligase VHL, demonstrating IC50 values of 4.1 μM and 7.0 μM in 1% and 10% DMSO solutions, respectively. It features a hydroxyproline residue and an isoxazole acetamide moiety, and effectively inhibits the binding of the fluorescence peptide derived from HIF1α (FAM-DEALA-Hyp-YIPD) to VHL.

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Key Properties

CAS Number1360616-29-0
MW410.43
FormulaC21H22N4O5
SMILESC(CC=1ON=C(C)C1)(=O)N2[C@H](C(NCC3=CC=C(C=C3)C4=CN=CO4)=O)C[C@@H](O)C2
TargetE1/E2/E3 Enzyme

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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VHL Ligand 38 (orb3174158)

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