SJF 1528

SKU: orb1693910

Description

This bifunctional degrader, composed of lapatinib linked to a VHL ligand, potently induces the degradation of wild-type EGFR (DC50 = 39.2 nM in OVCAR8) and HER2, and is active against Exon20Ins mutant EGFR. It inhibits proliferation in HER2-driven breast cancer models like SKBr3 cells (IC50 = 102 nM), supporting its use in targeted protein degradation research for oncology.

Research Area

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2230821-38-0
• MW: 1030.61
• Formula: C₅₅H₅₇ClFN₇O₈S
• SMILES: Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOc2ccc(cc2)-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)C(C)(C)C)cc1 |@:67|
• Target: PROTACs,EGFR,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

135157151