VHL Ligand 14

SKU: orb2565072

Description

VHL Ligand 14 (Compound 11) is a von Hippel-Lindau (VHL) binder designed for constructing PROTAC molecules that target the estrogen receptor α (ERα) for degradation, demonstrating an IC50 of 196 nM. This ligand enables the development of bifunctional degraders for probing ERα function in cancer research, applicable in both cellular and in vivo models.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2010986-87-3
• MW: 486.63
• Formula: C₂₅H₃₄N₄O₄S
• SMILES: C([C@@H](NC(C)=O)C(C)(C)C)(=O)N1[C@H](C(N[C@@H](C)C2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1
• Target: Ligands for E3 Ligase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

122529139