Verdinexor

SKU: orb1941091

Description

Verdinexor (KPT-335, KPT335) is an orally bioavailable, selective inhibitor of nuclear export (SINE), inhibits the function of nuclear export protein Exportin 1 (XPO1/CRM1) and the viability of Jurkat and canine DLBCL cells with IC50 of 8.7 nM and 13.3 nM, respectively; induces apoptosis in CLBL1 cells and primary canine DLBCL cells; reduces influenza a virus replication in vitro and in vivo; also inhibits XPO1-mediated transport and reduces RSV replication in vitro, shows effectivity against RSV A and B strains and reduces viral replication following prophylactic or therapeutic administration.Influenza Phase 1 Clinical.

Key Properties

• CAS Number: 1392136-43-4
• MW: 441.337
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₃F₆N₅O
• SMILES: O=C(NNC1=NC=CC=C1)/C=C\N2N=C(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)N=C2
• Target: Exportin-1
• Solubility: DMSO: 82 mg/mL (185.4 mM); Ethanol: 9 mg/mL (20.3 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

KPT-335 | KPT335

Quick Database Links

Gene Symbol

Exportin-1