Veratridine

SKU: orb1987226

Description

Veratridine is a steroidal alkaloid isolated from plants of the Veratrum and Schoenocaulon genera. It functions as a sodium channel neurotoxin that delays channel inactivation, leading to prolonged neuronal depolarization. This mechanism makes it a valuable research tool for studying ion channel function and excitotoxicity in both cellular and animal models of neurological disease.

Research Area

Neuroscience

Key Properties

• CAS Number: 71-62-5
• MW: 673.8
• Purity: >98%
• Formula: C₃₆H₅₁NO₁₁
• SMILES: [H][C@@]12CC[C@@]3([H])[C@]4(O)C[C@H](O)[C@@]5(O)[C@@]([H])(CN6C[C@@H](C)CC[C@@]6([H])[C@@]5(C)O)[C@]4(O)C[C@@]33O[C@]1(O)[C@H](CC[C@@]23C)OC(=O)c1ccc(OC)c(OC)c1
• Target: Ion channel
• Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).

Bioactivity

• Target IC50:
  Nav1.7:18.39 μM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

voltage-gated sodium channels, Veratridine, SodiumChannel, Sodium Channel, DRG neurons, 3-Veratroylveracevine, Inhibitor, Liliaceae, inhibit, Nav1.7, Neuro-2a, Na channels, Na+ channels

Compound Identifiers

PubChem CID

6280