Vasicinone

SKU: orb1297732

Description

Vasicinone is a small molecule with hepatoprotective properties and demonstrates significant antitussive, expectorant, and bronchodilatory activities for respiratory research. The (S)-enantiomer also shows in vitro antiproliferative activity against human gastric cancer cell lines like MGC-803.

Key Properties

• CAS Number: 486-64-6
• MW: 202.21
• Purity: 97.92% (May vary between batches)
• Formula: C₁₁H₁₀N₂O₂
• SMILES: O[C@H]1CCn2c1nc1ccccc1c2=O
• Target: Others
• Solubility: DMSO:12 mg/mL (59.34 mM)

Bioactivity

• In Vitro:
  The aerial parts of Peganum harmala L. (APP) is a well-known and effective herbal medicine in China, and has been commonly used for treating various ailments, including cough and asthma. OBJECTIVES: To evaluate the antitussive, expectorant, and bronchodilating effects of the quinazoline alkaloids (±)-vasicine (VAS), deoxyvasicine (DVAS) (both isolated from the alkaloid fraction of APP) and (±)-Vasicinone (VAO) (synthesized from VAS). CONCLUSIONS:Quinazoline alkaloids VAS, VAO, and DVAS have significant antitussive, expectorant, and bronchodilating activities. VAS, VAO, and DVAS are the active ingredients in APP, which can be used to treat respiratory disease.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

plant, stress, oxidative, quinazoline, vasica, Vasicinone, inhibit, Inhibitor, neurodegenerative, Parkinson, CYP17, disorders, Adhatoda, alkaloid

Compound Identifiers

PubChem CID

442935