Vasicinone

SKU: orb1217986

Description

Vasicinone may act as a hepatoprotective agent. (±)-Vasicinone has significant antitussive, expectorant, and bronchodilating activities, which can be used to treat respiratory disease.(S)-Vasicinone exhibits antiproliferative activity against human gastric cancer cells MCG-803.

Key Properties

• CAS Number: 486-64-6
• MW: 202.21
• Purity: >98% (HPLC)
• Formula: C₁₁H₁₀N₂O₂
• SMILES: C1CN2C(=NC3=CC=CC=C3C2=O)[C@H]1O
• Target: Others
• Solubility: DMSO:10 mM

Bioactivity

• In Vitro:
  Vasicinone (1~30 μM; 24 hours; SH-SY5Y cells) significantly reverses the paraquat-induced reduction in cell viability. Vasicinone (10 and 15 μM; 24 hours; SH-SY5Y cells) abates the paraquat-induced injury of SH-SY5Y cells by suppressing the MAPK signaling pathway, dose-dependently reduces the percentage of apoptotic cells and is capable of rescuing paraquat-induced apoptotic death. Vasicinone (10 and 15 μM; SH-SY5Y cells) attenuates the paraquat-induced accumulation of reactive oxygen species (ROS) and attenuates the paraquat-induced expression of apoptotic proteins. Cell Viability Assay Cell line: SH-SY5Y cells. Concentration: 1~30 μM. Incubation time: 24 hours. Result: Significantly reversed the paraquat-induced reduction in cell viability. Western blot analysis. Cell line: SH-SY5Y cells. Concentration: 10 and 15 μM. Incubation time: 24 hours. Result: Abated the paraquat-induced injury of SH-SY5Y cells by suppressing the MAPK signaling pathway. Apoptosis Analysis Cell line: SH-SY5Y cells. Concentration: 10 and 15 μM. Incubation time: 24 hours. Result: Dose-dependently reduced the percentage of apoptotic cells.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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