Valepotriate

SKU: orb1222591

Description

Valepotriate fraction can have sedative effects and affect behavioral parameters related to recognition memory. Valepotriates, a new class of cytotoxic and antitumor agents, they are very potent cytotoxic agents for the HTC hepatoma cells. Valepotriates may have a potential anxiolytic effect on the psychic symptoms of anxiety.

Key Properties

• CAS Number: 18296-44-1
• MW: 422.47
• Purity: >98% (HPLC)
• Formula: C₂₂H₃₀O₈
• SMILES: CC(C)CC(=O)O[C@H]3C=C1C(=CO[C@@H](OC(=O)CC(C)C)[C@@H]1[C@]23CO2)COC(C)=O
• Target: Antioxidant
• Solubility: In Vitro: DMSO : 100 mg/mL (236.70 mM)

Bioactivity

• In Vivo:
  Valepotriate showed significant anti-epileptic activity against MES-and PTZ-induced epilepsy at doses of 5, 10, and 20 mg/kg, and ED50 values for MES-and PTZ-induced epilepsy were 7.84 and 7.19 mg/kg, respectively. Furthermore, valepotriate (10 and 20 mg/kg) can significantly prolong sleeping time and shorten the latency time on the pentobarbital sodium-induced sleeping time test. Furthermore, valepotriate (5, 10, and 20 mg/kg) could significantly up-regulate the expression of GABAA, GAD65, and Bcl-2 and down-regulate the expression of caspase-3, but had no significant effect on the expression of GABAB.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Valtrate

Quick Database Links

Gene Symbol

Antioxidant