UV0155041

SKU: orb1223432

Description

UV0155041 is a potent, positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50 = 798 and 693 nM at human and rat mGlu4 receptors respectively).

Key Properties

• CAS Number: 1093757-42-6
• MW: 316.18
• Purity: >98% (HPLC)
• Formula: C₁₄H₁₅Cl₂NO₃
• SMILES: C1CC[C@H]([C@H](C1)C(=O)Nc1cc(cc(c1)Cl)Cl)C(=O)O
• Target: mGluR4
• Solubility: In Vitro: DMSO : 100 mg/mL (316.28 mM)

Bioactivity

• In Vivo:
  VU0155041 (31 nmol, 93 nmol; i. c. v.) reverses catalepsy induced by the dopamine D2 receptor antagonist Haloperidol (1.5 mg/kg, i.p.) in rats. VU0155041 (93 nnmol, 316 nmol; i. c. v.) reverses Reserpine (HY-N0480)-induced akinesia in rats. Animal model: Third ventricle cannulated (TVC) Male Sprague-Dawley rats (225-255 g). Dosage: 31 nmol, 93 nmol (10 μL). Administration: Intracerebroventrical injection, after the Haloperidol (1.5 mg/kg) treatment 2 hours. Result: Decreased the cataleptic effects of Haloperidol, and the effects still presented 30 min after infusion.
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• In Vitro:
  VU0155041 (10 μM) does not affect NMDA receptor currents in striatal medium spiny neurons.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

UV0155041 | UV-0155041 | UV 0155041

Quick Database Links

Gene Symbol

mGluR4