UUN44923

SKU: orb1218398

Description

UUN44923 is a FTO inhibitor. It may be useful for treating diseases assocd. with FTO targets, obesity, metabolic syndrome (MS) , type 2 diabetes (T2D) , Alzheimer's diseases, breast cancers, small- cell lung cancers, a human bone marrow striated muscle cancer, a pancreatic cancer, malignant glioblastoma and the like.

Key Properties

• CAS Number: 2243944-92-3
• MW: 391.25
• Purity: >98% (HPLC)
• Formula: C₁₈H₁₆Cl₂N₄O₂
• SMILES: O=C(NO)C1=CC=CC=C1NC2=C(Cl)C=C(C3=C(C)NN=C3C)C=C2Cl
• Target: FTO
• Solubility: DMSO:80 mg/mL (199.79 mM);Ethanol:80 mg/mL (199.79 mM)

Bioactivity

• In Vitro:
  FTO-IN-1 (50 μM) inhibits FTO enzyme activity by 62% in vitro. FTO-IN-1 (50 μM) inhibits the viability of SCLC-21H, RH30 and KP3 cells, with IC50s of 2.1 μM, 5.3 μM, and 5.6 μM, respectively.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

FTO-IN-1

Quick Database Links

Gene Symbol

FTO