USP7-IN-8

SKU: orb1298272

Description

This small molecule, also known as USP7-IN-8 or GNE-6776, is a selective USP7 inhibitor with an IC50 of 1.4 µM. It exhibits anticancer properties and is a valuable chemical probe for studying deubiquitinase biology in cancer research, both in vitro and in vivo.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 2009273-60-1
• MW: 347.41
• Purity: 99.31% (May vary between batches)
• Formula: C₂₁H₂₁N₃O₂
• SMILES: CCc1c(cnc(N)c1-c1ccc(O)cc1)-c1ccc(cc1)C(=O)NC
• Target: DUB
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (9.5 mM);DMSO:80 mg/mL (230.28 mM)

Bioactivity

• Target IC50:
  USP7:1.4 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Deubiquitinase, DUBs, anticancer, Inhibitor, inhibit, GNE6776, GNE-6776, GNE 6776, USP7 IN 8, USP7IN8, USP-7-IN-8, USP7-IN-8, USP7

Compound Identifiers

PubChem CID

122531799