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USP7-IN-8

SKU: orb1218516

Description

USP7-IN-8 is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM. USP7-IN-8 has anticancer effects.

Research Area

Epigenetics & Chromatin

Images & Validation

Key Properties

CAS Number2009273-60-1
MW348.4
Purity>98% (HPLC)
FormulaC20H20N4O2
SMILESCCc(c(-c(cc1)ccc1O)c(N)nc1)c1-c(cc1)cnc1C(NC)=O
TargetDUB
SolubilityDMSO:80mg/ml(230.08mM; need ultrasonic)

Bioactivity

In Vitro
USP7 or HAUSP (herpesvirus-associated USP) is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. USP7 is a eubiquitinase (DUB) that controls cell proliferation by altering the stability of Mdm2, p53, PTEN and FOXO4.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

GNE-6776

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Protocol Information

USP7-IN-8 (orb1218516)

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Available Sizes

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5 mg
$ 240.00
10 mg
$ 370.00
25 mg
$ 670.00
50 mg
$ 950.00
100 mg
$ 1,290.00
500 mg
$ 2,550.00