Uroplakin 3A Antibody

SKU: orb248591

Description

Uroplakin 3A (UPK3A) is a component of the asymmetric unit membrane (AUM). It is a highly specialized bio-membrane made by terminally differentiated urothelial cells. Uroplakin 3A may play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx, which may play an important role in preventing bacterial adherence through FimH bacterial protein binding leading to bladder infection. Uroplakin 3A has been shown as a helpful marker for the detection of bladder cancer.

Images & Validation

• Tested Applications: WB
• Dilution Range: Western blot: 0.5-1ug/ml
• Reactivity: Human
• Application Notes:
  The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the antibody to be titered up or down for optimal performance.

Key Properties

• Antibody Type: Primary Antibody
• Host: Rabbit
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Immunogen: A synthetic peptide, aa 260-279 (GASESSYTSVNRGPPLDRAE) of human Uroplakin 3A was used as the immunogen for this antibody.
• Purification: Protein A affinity chromatography
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

A KURKI Bioactive Biomaterials for Urethral and Pelvic Floor Repair trepo.tuni.fi, (2025)

PubMed:

Applications

IF

Reactivity

Human