UPF-1069

SKU: orb1301004

Description

UPF 1069 is a potent and selective inhibitor of PARP2, exhibiting an IC50 of 0.3 μM with approximately 27-fold selectivity over PARP1. This compound is a valuable chemical probe for studying PARP2-specific functions in DNA repair pathways and has been utilized in both cellular and animal models of relevant diseases.

Research Area

Cell Biology

Key Properties

• CAS Number: 1048371-03-4
• MW: 279.3
• Purity: >98%
• Formula: C₁₇H₁₃NO₃
• SMILES: O=C(COc1cccc2c1cc[nH]c2=O)c1ccccc1
• Target: PARP
• Solubility: Soluble in DMSO up to 40 mg/ml

Bioactivity

• Target IC50:
  PARP1:8 μM|PARP2:0.3 μM
• In Vivo:
  In organotypic hippocampal slices, PARP-2 inhibition with UPF-1069 (0.01-1 mM) causes a concentration-dependent exacerbation (up to 155%) of oxygen-glucose deprivation (OGD)-induced CA1 pyramidal cell death. Higher concentrations, acting on both PARP-1 and PARP-2, have no effect on OGD injury. In mouse mixed cortical cells exposed to OGD, UPF-1069 (1-10 mM) significantly reduces post-ischaemic damage.
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• In Vitro:
  UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM while inhibiting PARP1 with IC50 of 8 μM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, PARP, PARP2, PARP1, UPF1069, UPF-1069, UPF 1069, poly ADP ribose polymerase

Compound Identifiers

PubChem CID

25015515