UPF 1069

SKU: orb1301004

Description

UPF 1069

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1048371-03-4
• MW: 279.29
• Purity: 98.84%
• Formula: C₁₇H₁₃NO₃
• SMILES: O=C(COc1cccc2c1cc[nH]c2=O)c1ccccc1
• Target: PARP
• Solubility: DMSO:27.9 mg/mL (99.9 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.16 mM)

Bioactivity

• Target IC50:
  PARP1:8 μM|PARP2:0.3 μM
• In Vivo:
  In organotypic hippocampal slices, PARP-2 Inhibition with UPF-1069 (0.01-1 mM causes a concentration dependent exacerbation (up to 155%) of oxygen-glucose deprivation (OGD)-induced CA1 pyramidal cell death. Higher concentration , acting on both PARP-1 and PARP-2, have no effect on OGD injury. In mouse mixed cortical cells exposed to OGD, UPF-1069 (1-10 mM) significantly reduces post-ischaemic damage.
• In Vitro:
  UPF 1069 is a Selective PARP2 inhibitor with IC50 of 0.3 μM while inhibiting PARP1 with IC50 of 8 μM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, PARP, PARP2, PARP1, UPF1069, UPF-1069, UPF 1069, poly ADP ribose polymerase

Compound Identifiers

PubChem CID

25015515