UPF 1069

SKU: orb1223446

Description

UPF-1069 is a selective and potent PARP2 inhibitor. UPF-1069 induces apoptosis. UPF-1069 shows neuroprotective and anti-ischemic effects in vivo.

Key Properties

• CAS Number: 1048371-03-4
• MW: 279.29
• Purity: >98% (HPLC)
• Formula: C₁₇H₁₃NO₃
• SMILES: c1(=O)[nH]ccc2c(cccc12)OCC(=O)c1ccccc1
• Target: PARP1| PARP2
• Solubility: DMSO : ≥ 100 mg/mL 358.05 mM

Bioactivity

• In Vitro:
  UPF 1069 (Compound 55) is a PARP inhibitor, with IC50s of 8 and 0.3 μM for PARP-1 and PARP-2, respectively. UPF 1069 (1 μM) reduces the residual PARP activity by approximately 80% of PARP-1-deficient fibroblasts, but only slightly inhibits the enzymic activity in wild-type fibroblasts. UPF 1069 (0.1-1 μM) markedly enhances CA1 hippocampal damage. UPF 1069 (10 μM) also exacerbates oxygen-glucose deprivation (OGD) damage in organotypic hippocampal slices. However, UPF 1069 alleviates the damage cuased by OGD in mixed cortical cell cultures, shows a potent neuroprotective activity both at a concentration (1 μM) selectively acting on PARP-2 and at a concentration (10 μM) inhibiting both PARP-1 and PARP-2 activities.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

UPF-1069, UPF1069, UPF 1069

Quick Database Links

Gene Symbol

PARP1| PARP2