UNC6852

SKU: orb1940743

Description

UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC.(In Vitro):UNC6852 (10 μM; 1-72 hours) results in a decrease in the levels of both EED and EZH2. UNC6852 facilitates PRC2 degradation via VHL recruitment and reduces H3K27me3 levels and DLBCL cell proliferation. UNC6852 displays no cellular toxicity at concentrations up to 30 μM for HeLa Cells.

Key Properties

• CAS Number: 2688842-08-0
• MW: 394.42
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₂N₂O₅
• SMILES: CCc(n(Cc1ccccc1)c1ccc2)c(C(C(N)=O)=O)c1c2OCC(OC)=O
• Target: DNA/RNA Synthesis
• Solubility: In Vitro: DMSO : 100 mg/mL (120.05 mM)

Bioactivity

• In Vitro:
  Cell Proliferation Assay Cell line: DLBCL Cells. Concentration: 3 μM. Incubation time: 0 -10 days. Result: Exhibited anti-proliferative effects. Western blot analysis. Cell line: HeLa Cells. Concentration: 10 μM. Incubation time: 1 hours, 4 hours, 8 hours, 10 hours, 16 hours, 20 hours, 24 hours, 48 hours, 72 hours. Result: Resulted in a decrease in the levels of both EED and EZH2.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

DNA/RNA Synthesis