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UNC6852

SKU: orb1308745

Description

UNC6852

Research Area

Epigenetics & Chromatin, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number2688842-08-0
MW832.97
Purity98.69% (May vary between batches)
FormulaC43H48N10O6S
SMILESCc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCNC(=O)c2ccc(cc2)-c2cnc(NCc3ccco3)n3cnnc23)C(C)(C)C)cc1
TargetPROTACs,Ligands for Target Protein for PROTAC,Histone Methyltransferase
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (6 mM);DMSO:95 mg/mL (114.05 mM)

Bioactivity

Target IC50
EED:247 nM
In Vitro
UNC6852 (10 μM; 1-72 hours) results in a decrease in the levels of both EED and EZH2. UNC6852 facilitates PRC2 degradation via VHL recruitment and reduces H3K27me3 levels and DLBCL cell proliferation. UNC6852 displays no cellular toxicity at concentrations up to 30 μM for HeLa Cells.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

EED, Inhibitor, HistoneMethyltransferase, Histone Methyltransferase, inhibit, Ligands for Target Protein for PROTAC, LigandsforTargetProteinforPROTAC, PROTAC, PROTACs, PRC2, UNC 6852, UNC6852, UNC-6852

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 180.00
5 mg
$ 330.00
1 ml x 10 mM (in DMSO)
$ 440.00
10 mg
$ 500.00
25 mg
$ 780.00
50 mg
$ 1,030.00
100 mg
$ 1,400.00
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