UNC6852

SKU: orb1308745

Description

UNC6852

Research Area

Epigenetics & Chromatin, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2688842-08-0
• MW: 832.97
• Purity: 96.64%
• Formula: C₄₃H₄₈N₁₀O₆S
• SMILES: Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCNC(=O)c2ccc(cc2)-c2cnc(NCc3ccco3)n3cnnc23)C(C)(C)C)cc1
• Target: Histone Methyltransferase,PROTACs,Ligands for Target Protein for PROTAC
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (6 mM);DMSO:95 mg/mL (114.05 mM)

Bioactivity

• Target IC50:
  EED:247 nM
• In Vitro:
  UNC6852 (10 μM; 1-72 hours) results in a decrease in the levels of both EED and EZH2. UNC6852 facilitates PRC2 degradation via VHL recruitment and reduces H3K27me3 levels and DLBCL cell proliferation. UNC6852 displays no cellular toxicity at concentrations up to 30 μM for HeLa Cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EED, Inhibitor, HistoneMethyltransferase, Histone Methyltransferase, inhibit, Ligands for Target Protein for PROTAC, LigandsforTargetProteinforPROTAC, PROTAC, PROTACs, PRC2, UNC 6852, UNC6852, UNC-6852

Compound Identifiers

PubChem CID

146014466