UNC569

SKU: orb1306408

Description

UNC569 is a selective URAT1 inhibitor that blocks renal uric acid reabsorption. This small molecule research tool is used in vitro and in vivo to study hyperuricemia and gout pathophysiology, particularly in models of impaired uric acid excretion.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1350547-65-7
• MW: 396.5
• Purity: 99.67% (May vary between batches)
• Formula: C₂₂H₂₉FN₆
• SMILES: CCCCNc1ncc2c(nn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(F)cc1
• Target: TAM Receptor
• Solubility: DMSO:2.15 mg/mL (5.42 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.52 mM);H2O:Insoluble

Bioactivity

• Target IC50:
  Axl:37 nM(IC50)|Mer:2.9 nM(IC50)|Mer:4.3 nM(Ki)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Axl, ATP-competitive, anti-oncogenic, ALL, AKT, inhibit, Inhibitor, ERK, Mer, UNC 569, UNC569, UNC-569, Tyro3, TAM Receptor, TAMReceptor, pyrazolopyrimidine

Compound Identifiers

PubChem CID

53355503