UNC3866

SKU: orb1303295

Description

UNC3866 is a potent small molecule antagonist that disrupts the interaction between CBX7 and histone H3, as validated by AlphaScreen assays. This compound is a valuable chemical probe for studying Polycomb repressive complex 1 (PRC1) function in epigenetic regulation, cancer biology, and stem cell research in both cellular and biochemical experimental contexts.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 1872382-47-2
• MW: 795.02
• Purity: 98.00%
• Formula: C₄₃H₆₆N₆O₈
• SMILES: CCN(CC)CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(cc1)C(C)(C)C)C(=O)N[C@@H](CO)C(=O)OC
• Target: Histone Methyltransferase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.52 mM);DMSO:79.5 mg/mL (100 mM)

Bioactivity

• Target IC50:
  CBX4 chromodomain:94 nM(Kd)|CBX7 chromodomain:97 nM(Kd)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CBX7-H3, inhibit, HistoneMethyltransferase, Histone Methyltransferase, Inhibitor, UNC3866, UNC-3866, UNC 3866

Compound Identifiers

PubChem CID

101043861