UNC3866 TFA(1872382-47-2 free base)

SKU: orb1303294

Description

UNC3866 TFA is a potent and selective CBX7 chromodomain antagonist, effectively disrupting its interaction with histone H3K27me3 as validated by AlphaScreen. This compound is a valuable chemical probe for studying Polycomb repression in cancer epigenetics and stem cell biology, applicable in both in vitro and cellular assays.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 1872382-48-3
• MW: 909.04
• Purity: 98.60%
• Formula: C₄₅H₆₇F₃N₆O₁₀
• SMILES: CCN(CC)CCCC[C@@H](C(=O)N[C@@H](CO)C(=O)OC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C2=CC=C(C=C2)C(C)(C)C.C(=O)(C(F)(F)F)O
• Target: Histone Methyltransferase
• Solubility: DMSO:30 mg/mL (33 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

UNC3866 TFA(1872382 47 2 free base), UNC3866 TFA(1872382472 free base), UNC-3866 TFA(1872382-47-2 free base), UNC3866 TFA(1872382-47-2 free base), CBX7-H3, HistoneMethyltransferase, Histone Methyltransferase

Compound Identifiers

PubChem CID

155977586