UNC0646

SKU: orb1296112

Description

UNC0646 is a potent, selective dual inhibitor of the histone methyltransferases G9a and GLP, demonstrating nanomolar cellular activity and low cytotoxicity. It is a valuable chemical probe for epigenetic research, widely used in vitro and in vivo to study histone methylation's role in cancer, neurology, and development.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 1320288-17-2
• MW: 621.9
• Purity: 100.00%
• Formula: C₃₆H₅₉N₇O₂
• SMILES: COc1cc2c(NC3CCN(CC3)C3CCCCC3)nc(nc2cc1OCCCN1CCCCC1)N1CCCN(CC1)C(C)C
• Target: Histone Methyltransferase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6.43 mM);DMSO:30 mg/mL (48.24 mM)

Bioactivity

• Target IC50:
  G9a:6 nM|GLP:15 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

SAR, PKMT, UNC 0646, UNC0646, UNC-0646, p53, KMT1D, inhibit, HistoneMethyltransferase, Histone Methyltransferase, Inhibitor, H3K9me2, G9a, GLP, EHMT1, cell-penetration, chromatin

Compound Identifiers

PubChem CID

53315882