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UNC 0646

SKU: orb1220058

Description

UNC 0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50s: 6 nM/15 nM for G9a/GLP). UNC0646 potently blocks G9a/GLP methyltransferase activity in cells (IC50: 10 nM in MCF7 cells); exhibits low cellular toxicity (EC50: 4.7 μM in MCF7 cells).

Images & Validation

Key Properties

CAS Number1320288-17-2
MW621.9
Purity>98% (HPLC)
FormulaC36H59N7O2
SMILESCOC1=C(OCCCN2CCCCC2)C=C2N=C(N=C(NC3CCN(CC3)C3CCCCC3)C2=C1)N1CCCN(CC1)C(C)C
TargetG9a| GLP
SolubilityDMSO:30 mg/mL (48.24 mM; Need ultrasonic)

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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    1320288-17-2

    621.9

    C36H59N7O2

    1 ml x 10 mM (in DMSO), 5 mg, 10 mg, 50 mg, 25 mg, 100 mg
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Protocol Information

UNC 0646 (orb1220058)

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Available Sizes

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200 mg
500 mg
5 mg
$ 110.00
10 mg
$ 160.00
25 mg
$ 280.00
50 mg
$ 470.00
100 mg
$ 670.00