Umifenovir

SKU: orb1310932

Description

Umifenovir hydrochloride (Arbidol HCl) is a broad-spectrum antiviral small molecule that inhibits the entry of enveloped viruses by preventing viral-host cell membrane fusion. It has demonstrated antiviral activity in vitro and in vivo against influenza, coronaviruses, and other viruses, making it a useful tool for virology and antiviral mechanism research.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 131707-23-8
• MW: 513.9
• Purity: >98%
• Formula: C₂₂H₂₅BrN₂O₃S • HCl
• SMILES: Cl.CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12
• Target: SARS-CoV,Influenza Virus
• Solubility: Soluble in DMSO (up to at least 15 mg/ml) or in Ethanol (up to at least 10 mg/ml)

Bioactivity

• Target IC50:
  RNA viruses(FLU-A, RSV, HRV 14 and CVB3, enveloped and non-enveloped):2.7-13.8 microg/ml
• In Vitro:
  Arbidol inhibits the cell entry of HCV pseudoparticles of genotypes 1a, 1b, and 2a in a dose-dependent fashion. Arbidol also displays a dose-dependent inhibition of HCV membrane fusion, as assayed by using HCV pseudoparticles (HCVpp) and fluorescent liposomes. Arbidol is found to present potent inhibitory activity against enveloped and non-enveloped RNA viruses, including FLU-A, RSV, HRV 14 and CVB3 when added before, during, or after viral infection, with IC50 ranging from 2.7 to 13.8 mg/mL. Arbidol shows selective antiviral activity against AdV-7, a DNA virus, only when added after infection (therapeutic index (TI) = 5.5). Arbidol induces changes to viral mRNA synthesis of the PB2, PA, NP, NA, and NS genes in MDCK cultures infected with influenza A/PR/8/34. Arbidol interacts and modifies the physicochemical properties of the phospholipids in the membrane, having a significant effect on negatively charged phospholipids but a minor one on zwitterionic phospholipids. Arbidol is located at the interface of the membrane, participates in hydrogen bonding either with water or the phospholipid or both, and decreases the hydrogen bonding network of the phospholipids giving place to a phospholipid phase similar to the dehydrated solid one. Arbidol is found to have potent inhibitory activity against HTNV when added in vitro before or after viral infection, with IC50 of 0.9 mg/mL and 1.2 mg/mL, respectively.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Arbidol

Compound Identifiers

PubChem CID

9958103