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UMI-77

SKU: orb1224833

Description

A potent and selective Mcl-1 inhibitor with Ki of 0.49 uM; displays >10 fold selectivity against Bcl-w, Bfl-1, Bcl-xL and Bcl-2; inhibits cell growth and induces apoptosis in pancreatic cancer cells; blocks the heterodimerization of Mcl-1/Bax and Mcl-1/Bak in cells; inhibits tumor growth in BxPC-3 xenograft model.

Images & Validation

Key Properties

CAS Number518303-20-3
MW468.3415
Purity>98% (HPLC)
FormulaC18H14BrNO5S2
SMILESC1=CC=C2C(=C1)C(=CC(=C2O)SCC(=O)O)NS(=O)(=O)C3=CC=C(C=C3)Br
TargetBcl-2
SolubilityDMSO: ≥ 28 mg/mL

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

UMI-77, UMI77, UMI 77

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    C18H14BrNO5S2

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Protocol Information

Available Sizes

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200 mg
500 mg
2 mg
$ 100.00
5 mg
$ 140.00
10 mg
$ 210.00
25 mg
$ 360.00
50 mg
$ 580.00
100 mg
$ 830.00