Tyrphostin B44, (+) enantiomer

SKU: orb1305913

Description

The (+) enantiomer of Tyrphostin B44 is a selective EGFR kinase inhibitor exhibiting an IC50 of 0.86 μM. It demonstrates lower potency compared to its (-) enantiomer counterpart. This compound is a valuable research tool for studying EGFR signaling in cancer biology through in vitro enzymatic and cellular assays.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 133550-37-5
• MW: 308.33
• Purity: 98.80%
• Formula: C₁₈H₁₆N₂O₃
• SMILES: C[C@H](NC(=O)C(=C\c1ccc(O)c(O)c1)\C#N)c1ccccc1
• Target: EGFR
• Solubility: DMSO:60 mg/mL (194.6 mM);10% DMSO+90% Saline:2.5 mg/mL (8.11 mM)

Bioactivity

• Target IC50:
  EGFR:0.86 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tyrphostin AG 835, Tyrphostin B 50, Tyrphostin B44, enantiomer, Tyrphostin B44, (+) enantiomer, Tyrphostin B-44, (+) enantiomer, Tyrphostin B50, Tyrphostin B-50, Tyrphostin AG835, Tyrphostin AG-835, inhibit, non-metastatic tumors, INBL, Inhibitor, HER1, ErbB-1, EGFR, Epidermal growth factor receptor, antitumor, CALO, (+)-Tyrphostin B44, cervical carcinoma cell

Compound Identifiers

PubChem CID

5328769