Tyrphostin B44, (+) enantiomer

SKU: orb1218921

Description

Tyrphostin B44, (+) enantiomer is an inhibitor of epidermal growth factor receptor (EGFR) kinase with IC50 of 0.86 μM and has less active than the (-) enantiomer.

Key Properties

• CAS Number: 133550-37-5
• MW: 308.33
• Purity: >98% (HPLC)
• Formula: C₁₈H₁₆N₂O₃
• SMILES: C[C@@H](c1ccccc1)NC(/C(/C#N)=C/c(cc1)cc(O)c1O)=O
• Target: EGFR
• Solubility: In Vitro: DMSO : ≥ 100 mg/mL (324.33 mM)

Bioactivity

• In Vitro:
  (+)-Tyrphostin B44 (Tyrphostin AG 835) (Compound B50) (0-100 μM) inhibits cell survival with EC50 values of 3.12, 12.5 and 12.5 μM against CALO, INBL and HeLa cells, respectively.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

EGFR