Tyrphostin B44, (+) enantiomer

SKU: orb1218921

Description

Tyrphostin B44, (+) enantiomer is an inhibitor of epidermal growth factor receptor (EGFR) kinase with IC50 of 0.86 μM and has less active than the (-) enantiomer.

Images & Validation

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Key Properties

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CAS Number	133550-37-5
MW	308.33
Purity	>98% (HPLC)
Formula	C₁₈H₁₆N₂O₃
SMILES	C[C@@H](c1ccccc1)NC(/C(/C#N)=C/c(cc1)cc(O)c1O)=O
Target	EGFR
Solubility	In Vitro: DMSO : ≥ 100 mg/mL (324.33 mM)

Bioactivity

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In Vitro	(+)-Tyrphostin B44 (Tyrphostin AG 835) (Compound B50) (0-100 μM) inhibits cell survival with EC50 values of 3.12, 12.5 and 12.5 μM against CALO, INBL and HeLa cells, respectively.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Quick Database Links

Gene Symbol

EGFR

Protocol Information

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