Tyrphostin 9

SKU: orb1305423

Description

Originally developed as an EGFR tyrosine kinase inhibitor, Tyrphostin A9 (SF 6847) was also employed as an agricultural acaricide. It serves as a research tool in biochemical studies for investigating EGFR signaling pathways in cellular models.

Research Area

Cardiovascular Research, Infectious Disease & Virology, Signal Transduction

Key Properties

• CAS Number: 10537-47-0
• MW: 282.38
• Purity: >98%
• Formula: C₁₈H₂₂N₂O
• SMILES: CC(C)(C)c1cc(C=C(C#N)C#N)cc(c1O)C(C)(C)C
• Target: Kinase
• Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml)

Bioactivity

• Target IC50:
  EGFR:460 μM|PDGFR:0.5 μM
• In Vivo:
  SF 6847 prevents the PDGF-induced tyrosine phosphorylation of LGF in caveolae of human fibroblasts, suggesting that PDGF-BB-mediated activation of LRP requires tyrosine phosphorylation and thereby activates PDGFR-β. Additionally, SF 6847 inhibits the replication of Herpes Simplex Virus Type 1 (HSV-1) with an IC50 of 40 nM and enhances the inclusion of MAPT exon 10 in SHSY-5Y cells by twofold at a concentration of 1.6 μM. At 1 mM, it blocks the strain-induced stimulation of DNA synthesis in fetal lung cells. SF 6847 partially reverses vanadate-induced HSV-1 plaque formation at 50 nM and reduces viral phosphoprotein phosphorylation in a dose-dependent manner at concentrations below 400 nM. However, the reduction in protein synthesis induced by SF 6847 at concentrations below 800 nM is not dose-dependent.
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Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tyrphostin a9; Malonoben; AG-17; SF 6847; RG-50872

Compound Identifiers

PubChem CID

5614