Tyrphostin AG 528

SKU: orb1302784

Description

Tyrphostin AG 528 (B66) is a dual inhibitor of EGFR and ErbB2 tyrosine kinases, exhibiting IC50 values of 4.9 µM and 2.1 µM, respectively. It is a research tool used in vitro to study oncogenic signaling pathways and explore potential therapeutic strategies in cancer research, particularly involving the ErbB receptor family.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 133550-49-9
• MW: 306.32
• Purity: 99.74% (May vary between batches)
• Formula: C₁₈H₁₄N₂O₃
• SMILES: Oc1ccc(\C=C(\C#N)C(=O)N2CCc3ccccc23)cc1O
• Target: EGFR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.53 mM);DMSO:55 mg/mL (179.55 mM)

Bioactivity

• Target IC50:
  ErbB2:2.1 μM|EGFR:4.9 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tyrphostin AG528, Tyrphostin AG-528, Tyrphostin B 66, Tyrphostin B66, Tyrphostin B-66, Tyrphostin AG 528, AG 528, AG528, AG-528, ErbB2, EGFR

Compound Identifiers

PubChem CID

1838042